LATEST PROJECTS
Thesis | Novel Immuno-oncological Diagnostic/Therapeutic Paradigm for Metastatic Melanoma
My current project focuses on melanoma, and using the technology to diagnose and treat this indication. Under the supervision of Dr. Katarzyna Sawicka, and in collaboration with the laboratory of Dr. Berhane Ghebrehewit, I have dived into the world of immunology and the interactions of the complement system with cancer proliferation. The complement system is one of the oldest components of innate immunity, with the protein C1q playing a major role in its classical pathway. For the project, we are focusing on the this C1q protein, along with its two receptors, gC1qR, and cC1qR - all of which have been linked to involvement in cancer cell proliferation in studies conducted by the Ghebrehewit lab. In a breast cancer model, it has been proven that dosing cells with certain antibodies to the C1q and gC1qR caused time dependent cell growth inhibition. The long-term goal of my project is to confirm the existence of the receptors on metastatic melanoma cells, and to create an antibody patch that can effectively block the receptors to affect tumor growth and progression.
Focused on optimizing stability and delivery of proteins through the formulations of the ImmunoMatrix Patch. Performed research on the stability of electrospun horseradish peroxidase in various formulations and morphologies of the patch. Conducted studies on the ability of the ImmunoMatrix patch to delivery HRP transdermally in comparison to thin film and microneedle counterparts. With this work, we were able to optimize the efficacy of the technology.
Project | The Effects of Low Intensity Vibration on Alcohol Induced Bone Marrow Adiposity (Rat Model)
Used microCT analysis to study the effects of chronic alcohol consumption on murine bone morphology and potential of low intensity vibrations to decrease induced negative effects. Used histological methods to determine possible increase in murine bone marrow adiposity through chronic alcohol consumption and mitigative effects of low intensity vibrations.
To see more or discuss possible work let's talk >>
Project | 01
Project | 02
Project | 03